Nystatin Tablets 500000IU
Each tablet contains 500 000 units nystatin.
Gastrointestinal absorption of nystatin is insignificant. Most
orally administered nystatin is passed unchanged in the stool.
Nystatin is an antibiotic with antifungal activity against a wide
variety of yeasts and yeast-like fungi. The antifungal activity of
nystatin is at least in part dependent on its binding to a sterol
moiety, primarily ergosterol, present in the membrane of sensitive
fungi, which results in an increase in the permeability of the
membrane and leakage of intra-cellular components.
Nystatin exhibits no appreciable activity against bacteria,
protozoa or viruses.
Nystatin tablets are indicated for the treatment of intestinal candidiasis.
Patients with a history of hypersensitivity to any component.
Pregnancy and Lactation
Safety of use during pregnancy has not been established. It is not
known whether nystatin is excreted in human milk.
DOSAGE AND DIRECTIONS FOR USE
The usual dose is one tablet (500 000 units) three times daily.
This dosage may be increased to two tablets (1 000 000 units) three
times daily if intestinal fungi are not adequately suppressed. The
treatment should generally be continued for at least 48 hours after
clinical cure to prevent relapse.
SIDE EFFECTS AND SPECIAL PRECAUTIONS
Nystatin may produce diarrhoea and gastro-intestinal disturbance,
nausea and vomiting. Rash, including urticaria, has been reported.
Stevens-Johnson syndrome has been reported very rarely.
Nystatin tablets should not be used for the treatment of systemic mycoses.
If irritation or sensitization develops, treatment should be
Round, biconvex, chocolate coloured tablets.
Store at room temperature not exceeding 25°C.
KEEP OUT OF REACH OF CHILDREN.